Work on the $43m, 18,000 square metre Bunnings Warehouse on John Oxley Drive is on schedule.
Bunnings' state operations manager NSW north, Cheryl Williams, said the construction work is progressing as planned.
"Once complete, the existing team will transfer to the new store and will be joined by more than 60 new team members," she said.
"Stock from the existing site will be distributed to other Bunnings stores and racking will be recycled within the store network.
"Bunnings has been a part of the Port Macquarie community since 2003 and we are looking forward to providing the local community with an even wider range of products in a bigger and better store."
The new Port Macquarie is expected to open its doors in early 2019.
The new mega outlet is expected to create more than 60 jobs for local residents - the current store on Lake Road boasts some 130 team members - with a further 250 jobs during the construction phase.